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Drug intelligence / Profile preview
PSMA-1-MMAE-Pc413
- Development stage
- Preclinical
- Lead developer
- Case Western Reserve University
01
Overview
PSMA-1-MMAE-Pc413: sourced facts only. name: "Using a bifunctional PSMA ligand, a novel theranostic PSMA-targeting conjugate was synthesized, which integrated both the photosensitizer Pc413 and the microtubular inhibitor monomethyl auristatin E (MMAE) in one simple molecule, PSMA-1-MMAE-Pc413." [DOI:10.1158/1538-7445.am2024-4570]; target: "Using a bifunctional PSMA ligand, a novel theranostic PSMA-targeting conjugate was synthesized, which integrated both the photosensitizer Pc413 and the microtubular inhibitor monomethyl auristatin E (MMAE) in one simple molecule, PSMA-1-MMAE-Pc413." [DOI:10.1158/1538-7445.am2024-4570]; developer: "1Case Western Reserve University, Cleveland, OH." [DOI:10.1158/1538-7445.am2024-4570]; stage: "Finally, the antitumor activity of PSMA-1-MMAE-Pc413 was tested in mice with PC3pip tumors with and without light irradiation." [DOI:10.1158/1538-7445.am2024-4570]
02
Targets
PSMA (Prostate-specific membrane antigen)
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