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PSMA-CAR NK cells
- Development stage
- Unknown
- Lead developer
- BOE Regenerative Medicine Technology
- Modality
- CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
PSMA-CAR NK cells are allogeneic, peripheral blood-derived natural killer (NK) cells genetically engineered to express a chimeric antigen receptor (CAR) targeting prostate-specific membrane antigen (PSMA). Developed by the Chinese Academy of Medical Sciences and Peking Union Medical College in collaboration with BOE Regenerative Medicine Technology, these cells are designed to target and eliminate PSMA-expressing prostate cancer cells. In early-phase clinical trials, PSMA-CAR NK cells are being evaluated as an off-the-shelf cell therapy for patients with metastatic castration-resistant prostate cancer (mCRPC), demonstrating a favorable safety profile and preliminary anti-tumor activity without inducing cytokine release syndrome (CRS) or graft-versus-host disease (GVHD).
- Other names
- anti-PSMA CAR-NK cellsPSMA CAR-NK cellsPSMA-directed CAR NK cellsPSMA-targeted CAR-NK cells
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