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PSMA CAR-T
- Development stage
- Preclinical
- Lead developer
- YaKe Biotechnology
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
PSMA CAR-T is an investigational chimeric antigen receptor (CAR) T-cell therapy being developed by YaKe Biotechnology for the treatment of prostate cancer. The therapy involves engineering a patient's T cells to express a CAR that specifically recognizes Prostate-Specific Membrane Antigen (PSMA), a cell-surface protein highly expressed on the surface of prostate cancer cells, including metastatic castration-resistant prostate cancer (mCRPC). Upon re-infusion into the patient, these engineered T cells target and eliminate PSMA-positive tumor cells through T-cell mediated cytotoxicity. The program is currently in the preclinical stage of development.
- Other names
- PSMA-targeted chimeric antigen receptor T-cell therapyPSMA-CAR-T cell therapyCAR-T PSMA
02
Targets
PSMA (Prostate-specific membrane antigen)
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