Drug intelligence / Profile preview

PSMA-CAR-TNK

Development stage
Preclinical
Lead developer
Sorrento Therapeutics
Modality
CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
Administration
Intravenous
01

Overview

**PSMA-CAR-TNK** is an investigational, off-the-shelf CAR-engineered natural killer cell therapy developed through a collaboration between Conkwest and Sorrento Therapeutics. It uses Conkwest's NK-92-derived Neukoplast cell line engineered with a chimeric antigen receptor designed to recognize prostate-specific membrane antigen, a tumor-associated cell-surface target commonly expressed in prostate cancer and other solid tumors. The product concept was part of the companies' CAR-TNK program, combining NK-92 effector-cell biology with Sorrento-derived antibody and CAR technologies to generate scalable allogeneic antitumor cell therapies.

02

Targets

PSMA (Prostate-specific membrane antigen)

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