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PSMA-targeted OC-IgT

Development stage: Unknown
Lead developer: Shenzhen Geno-Immune Medical Institute
Modality: CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Intravenous, Intratumoral

Overview

PSMA-targeted OC-IgT is an autologous chimeric antigen receptor T-cell (CAR-T) therapy developed by the Shenzhen Geno-Immune Medical Institute in collaboration with Shenzhen People's Hospital. It consists of patient-derived T lymphocytes genetically engineered to express a chimeric antigen receptor (CAR) targeting prostate-specific membrane antigen (PSMA; glutamate carboxypeptidase 2). PSMA is highly expressed on the tumor-associated neovasculature of various solid tumors, including ovarian cancer. Upon infusion, these modified T cells specifically recognize and eliminate PSMA-expressing ovarian cancer cells. The therapy has been evaluated in Phase 1 clinical trials in China for the treatment of recurrent or refractory ovarian cancer.

Other names: autologous ovarian cancer immunogene-modified T cellsOC-IgT cellsPSMA-targeted OC-IgT cells

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