Drug intelligence / Profile preview

PSORI-CM01

Development stage
Phase 2
Lead developer
Guangdong Provincial Hospital of Traditional Chinese Medicine
Modality
Small Molecules
Administration
Oral
01

Overview

PSORI-CM01 is a Chinese herbal medicine formula developed for the treatment of psoriasis vulgaris and stable plaque psoriasis. It is composed of multiple medicinal herbs and is administered orally as a granule or decoction. The formula has demonstrated efficacy in reducing relapse rates and improving clinical symptoms in moderate-to-severe psoriasis patients when used alone or in combination with topical therapies[1][4][5]. Mechanistically, network pharmacology and clinical studies suggest that its therapeutic effects are mediated by modulation of microRNA expression (notably miR-20a-3p and miR-3184-3p), leading to increased autophagy, reduced keratinocyte proliferation, anti-inflammatory effects, regulation of apoptosis, and immunomodulation[7]. Key chemical constituents include paeoniflorin, liquiritin, astilbin (and related flavonoids), engeletin derivatives, glycyrrhizic acid among others[5]. Clinical trials have been conducted primarily in China.

Brand names
PSORI-CM01PSORI-CM-01PSORI-CM 01YXBCM01YXBCM-01YXBCM 01
Other names
PSORI-CM01 formulaPSORI-CM-01 formulaPSORI-CM 01 formulaPSORI-CM 01PSORI-CM01PSORI-CM-01YXBCM01 granuleYXBCM-01 granuleYXBCM 01 granule
02

Targets

KRT6A (Keratin 6A)

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