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psorospermum febrifugum extract
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
*Psorospermum febrifugum* extract is a botanical therapeutic derived from the African medicinal shrub *Psorospermum febrifugum*, currently under investigation for the topical treatment of acne vulgaris. The extract's efficacy is attributed to a synergistic combination of bioactive compounds, including xanthones (such as psorospermin and garcinone E), mangiferin, and betulinic acid. Its primary mechanism involves the inhibition of microbial lipases, which prevents the hydrolysis of sebum triglycerides into irritating free fatty acids. Additionally, the extract demonstrates potent antibacterial activity against *Cutibacterium acnes*, alongside anti-inflammatory, antioxidant, and keratolytic properties that address multiple stages of acne pathogenesis.
- Other names
- Psorospermum febrifugum Spach extractPsorospermum febrifugum botanical extract
02
Targets
PNLIP (Pancreatic triacylglycerol lipase)
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