PSP-2

PSP-2 (1,2-bis(bis(dimethylphosphorothioylmethyl)phosphino)ethane) is a novel, high-affinity, membrane-permeant copper(I) (Cu(I)) chelator with a low-zeptomolar dissociation constant. Developed by researchers at the Georgia Institute of Technology, PSP-2 selectively depletes intracellular copper levels without affecting other trace metals like zinc or iron. By restricting copper availability, PSP-2 suppresses angiogenesis and tumor growth, demonstrating efficacy in preclinical models of lung cancer (such as H460 and Lewis lung carcinoma grafts) and reducing PD-L1 expression. Additionally, PSP-2 is being investigated for neuroprotective applications, where it prevents copper-associated neurotoxicity, reduces neuronal death, and promotes axon regeneration following traumatic or ischemic nerve injuries.

Other names

1,2-bis(bis(dimethylphosphorothioylmethyl)phosphino)-ethan1,2-bis(bis(dimethylphosphorothioylmethyl)phosphino)ethane