PSPC1 small interfering RNA

PSPC1 small interfering RNA is an experimental **RNA therapy** consisting of a gene-silencing small interfering RNA designed to reduce expression of **paraspeckle component 1**, a nuclear paraspeckle protein implicated in DNA damage response and survival of BRCA1 or BRCA2-mutated tumor cells. In the cited preclinical breast and ovarian cancer study, PSPC1 siRNA was used as a research therapeutic to suppress PSPC1 and synergize with the PARP inhibitor olaparib, increasing DNA double-strand break signaling, reducing p-ATM and DNA-PKcs-associated repair responses, abrogating the G2/M checkpoint, and promoting apoptosis. No unique proprietary drug name, sponsoring company, clinical-stage program, or commercial manufacturer was identified from the provided context; the agent appears to be a target-specific research siRNA rather than a clearly defined branded development candidate.

Other names

PSPC1 siRNAPSPC-1 siRNAPSPC 1 siRNAparaspeckle component 1 small interfering RNAparaspeckle component 1 siRNA