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PT-DDC
- Development stage
- Preclinical
- Modality
- Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
PT-DDC is an experimental **PSMA-targeted PAMAM dendrimer-drug conjugate** being developed preclinically for prostate cancer theranostics and targeted chemotherapy. It is built on a generation-4 poly(amidoamine) dendrimer scaffold carrying the **maytansinoid payload DM1**, a **lysine-urea-glutamate PSMA-targeting moiety**, a **NOTA chelator** for copper-64 PET imaging, and a **Cy5 optical imaging dye**. The construct is designed to bind **prostate-specific membrane antigen**, undergo tumor-selective uptake in PSMA-expressing prostate cancer, and then release DM1 in a glutathione-dependent manner to disrupt microtubules and inhibit tumor growth. Published evidence for PT-DDC is limited to preclinical studies, with no clear evidence of clinical development or commercialization.
- Other names
- PSMA-targeted dendrimer-drug conjugatemultimodal PSMA-targeted PAMAM dendrimer-drug conjugate
02
Targets
PSMA (Prostate-specific membrane antigen)
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