Ptac2S

Ptac2S (also known as [Pt(DMS)]) is a novel platinum(II) complex containing acetylacetonate (acac) and dimethylsulfoxide (DMS) ligands. Unlike cisplatin, which primarily targets genomic DNA, Ptac2S operates on non-genomic targets and has demonstrated the ability to circumvent cisplatin resistance in epithelial ovarian carcinoma (EOC) cell lines such as SKOV-3. It exhibits potent antitumor and antiangiogenic activities, significantly inhibiting tumor growth, cell proliferation, and microvessel density in preclinical models of renal cell carcinoma and ovarian cancer. Its mechanism of action involves the downregulation of pro-angiogenic factors, including vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP1, MMP2, and MMP9), as well as significant alterations in cellular metabolism and lipid expression.

Other names

[Pt(O,O'-acac)(γ-acac)(DMS)]platinum(II) complex with acetylacetonate and dimethylsulfoxide