pterin-6-yl-methyl-monophosphate

Pterin‑6‑yl‑methyl‑monophosphate is a synthetic small molecule belonging to the class of pterins and derivatives. It features a pterin ring system linked via a methylene group to a monophosphate moiety. This compound is primarily used as an experimental or discovery agent in biochemical research and drug discovery. Its main known biological activity is as an inhibitor of bacterial dihydropteroate synthetase (DHPS), an enzyme essential for folate biosynthesis in bacteria but absent in mammals. By inhibiting DHPS, it can disrupt folate production, which is critical for cell growth and survival in prokaryotes[1][5][7]. There are no approved clinical indications or marketed formulations for this compound.

Other names

((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methoxy)phosphonic acid[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methoxy]phosphonic acid6-hydroxymethylpterin monophosphate(2-amino-4-oxo–3H-pteridin–6–yl)methyl dihydrogen phosphate