pteroate-rhodamine B conjugate

pteroate-rhodamine B conjugate is a fluorescently labeled small molecule bioconjugate designed for the targeted imaging of folate receptor (FR) positive tissues. It comprises a pteroate targeting ligand (a folate analog), a rhodamine B fluorescent reporter, and a chelating core capable of sequestering cytotoxic agents or radiotracers. Synthesized via solid-phase peptide synthesis, the conjugate selectively binds to folate receptors—which are overexpressed in various malignancies such as ovarian, lung, and endometrial cancers, as well as in certain inflammatory cells—and is internalized through receptor-mediated endocytosis. This makes it a versatile tool for fluorescence-guided intra-operative imaging and potential theranostic applications.

Other names

pteroate rhodamine Bpteroate-rhodamine B bioconjugate