Drug intelligence / Profile preview

Pterocarpus erinaceus extract

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

Pterocarpus erinaceus extract is a plant-derived preparation obtained from various parts (primarily bark, root, leaf, and heartwood) of Pterocarpus erinaceus, a medicinal tree widely used in West African traditional medicine. Extracts contain multiple biologically active compounds, including flavonoids, terpenoids, phenols, alkaloids, tannins, phytate, triterpenes (e.g. friedelin, lupeol), and epicatechin. Pharmacological studies have demonstrated antioxidant, anti-inflammatory, analgesic, antibacterial, antifungal, and potentially neuroprotective activities. In vitro and in vivo models suggest inhibition of lipoxygenase, suppression of lipid peroxidation, and scavenging of free radicals[1][2][5][6][8]. There is also preliminary evidence the "kino" extract may act as a selective γ-secretase inhibitor, potentially relevant to Alzheimer's disease therapy[5]. These findings support its traditional use for conditions such as inflammation, pain, gastrointestinal disorders, infections, and possibly cognitive disorders.

Other names
Pterocarpus erinaceus kino extractAfrican Rosewood extract
02

Targets

GSEC (Gamma-Secretase Complex)15-LOX (Lysyl Oxidase)

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