Drug intelligence / Profile preview

pterocarpus indicus exudate

Development stage
Phase 2
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

*Pterocarpus indicus* exudate, commonly known as Narra resin or kino, is a deep-red sap obtained from the bark of the *Pterocarpus indicus* tree, a species native to Southeast Asia and the Pacific islands. This natural product is characterized by a high concentration of bioactive polyphenolic compounds, specifically pterocarpans such as pterocarpin and homopterocarpin, alongside flavonoids like isoliquiritigenin and formononetin. These constituents confer potent antioxidant, anti-inflammatory, and antimicrobial properties. Traditionally used in folk medicine to treat diverse conditions including diarrhea, bladder stones, and skin infections, the exudate is currently the subject of clinical investigation for its potential to improve renal function and manage glycemic levels. Its mechanism of action is primarily attributed to the inhibition of pro-inflammatory mediators and the scavenging of reactive oxygen species.

Brand names
Narra
Other names
narra resinnarra sapkinoangsana resindragon's bloodred narra sap
02

Targets

TNFA (Tumor necrosis factor alpha (soluble))NF-κBPTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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