PTH(7-33)-CBD

PTH(7-33)-CBD is a bone-targeted parathyroid hormone (PTH) antagonist designed to prevent breast cancer bone metastases. It consists of an N-terminally truncated analog of parathyroid hormone, PTH(7-33), fused to the inert collagen-binding domain (CBD) of ColG collagenase from *Clostridium histolyticum*. This fusion directs the delivery of the PTH antagonist to the bone matrix, where it blocks the action of parathyroid hormone-related peptide (PTHrP), a peptide secreted by breast cancer bone metastases that stimulates bone turnover and creates cavities for tumor growth. In preclinical models, PTH(7-33)-CBD has demonstrated the ability to reduce overall tumor burden in bone, decrease cortical bone destruction, and exhibit selective cytotoxicity against breast cancer cells without causing hypocalcemia or general toxicity.

Other names

PTH(7-33)-CBD