Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Pthlh inhibitor
- Development stage
- Preclinical
- Lead developer
- University of Pennsylvania
- Modality
- Antibody-Based Therapeutics, Small Molecules
01
Overview
A Pthlh inhibitor is a therapeutic agent designed to block the activity of Parathyroid Hormone-Like Hormone (PTHLH), also known as Parathyroid Hormone-Related Protein (PTHrP). In the context of pancreatic ductal adenocarcinoma (PDAC), PTHLH is identified as a key driver of epithelial-to-mesenchymal transition (EMT) and metastasis, particularly in tumors with p120 catenin loss. PTHLH functions as a secreted factor that binds to its cognate receptor, triggering cytosolic calcium (Ca2+) release and the subsequent activation of CaMKII signaling. Preclinical research indicates that genetic deletion or pharmacologic inhibition of PTHLH can impair tumor cell proliferation and migration, and reduce metastatic burden in vivo, suggesting that targeting the PTHLH-calcium signaling axis may offer therapeutic benefits for patients with aggressive pancreatic cancer.
- Other names
- PTHrP inhibitorParathyroid hormone-related protein inhibitorParathyroid hormone-like hormone inhibitor
02
Targets
PTH1R (Parathyroid hormone/Parathyroid hormone-related peptide receptor type 1)
Beyond the preview
Go deeper on Pthlh inhibitor.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Pthlh inhibitor.