Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
PTLS-001
- Development stage
- Preclinical
- Lead developer
- Primetime
- Modality
- Small Molecules
- Administration
- Parenteral
01
Overview
PTLS-001 (also known as PLS5) is a preclinical-stage small molecule mutual prodrug (Metual®) consisting of the chemotherapeutic agent paclitaxel covalently linked to the antidiabetic drug metformin. Developed by Primetime Life Sciences, PTLS-001 is designed to treat ovarian cancer by simultaneously delivering both active agents to the tumor site. Upon cleavage, paclitaxel acts as a microtubule stabilizer to inhibit cell division, while metformin targets mitochondrial complex I and PEN2 to activate AMPK, potentially overcoming chemoresistance and synergistically inhibiting tumor growth.
- Other names
- Metformin-paclitaxel mutual prodrugMetual prodrug of paclitaxel and metforminmetformin + paclitaxel mutual prodrug
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)ND1 (Mitochondrial electron transport chain complex I)TUBB (Tubulin (alpha and beta subunits))
Beyond the preview
Go deeper on PTLS-001.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on PTLS-001.