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PTM-001
- Development stage
- Phase 2
- Lead developer
- PTM Therapeutics
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
01
Overview
PTM-001 is a monoclonal antibody developed by PTM Therapeutics, originally licensed from Emory University and the University of Michigan, for immunomodulatory therapy. It is being investigated primarily for its potential to treat inflammatory diseases such as hidradenitis suppurativa and ulcerative colitis. The drug acts as an immunomodulator, with its mechanism involving stimulation of focal adhesion protein tyrosine kinase. Preclinical studies have shown that it targets a glycan epitope found on human and mouse intestinal epithelial tissue, supporting its use in models of colitis. Clinical trials are ongoing to assess its efficacy in reducing inflammation and modulating immune responses in patients with hidradenitis suppurativa[2][3][5][9].
- Other names
- PTM-001PTM001PTM 001
02
Targets
sLeX (Sialyl-Lewis X antigen)
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