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Drug intelligence / Profile preview
pTVG-HP plasmid DNA vaccine
- Development stage
- Phase 2
- Lead developer
- Madison Vaccines
- Modality
- Prophylactic Vaccines → Vaccines & Immunotherapeutics, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intradermal
01
Overview
The pTVG-HP plasmid DNA vaccine is designed to stimulate the host immune system by generating a cytotoxic T lymphocyte (CTL) response against prostatic acid phosphatase (PAP)-expressing cells. It is primarily used in the treatment of prostate cancer, particularly in combination with checkpoint inhibitors like pembrolizumab or nivolumab to enhance its efficacy.
- Brand names
- MVI-816MVI816MVI 816
- Other names
- PAP DNA vaccineprostatic acid phosphatase DNA vaccine
02
Targets
PAP (Prostatic acid phosphatase)
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