Drug intelligence / Profile preview

Pueraria mirifica extract

Development stage
Unknown
Lead developer
Dhurakij Pundit University
Modality
Small Molecules
Administration
Oral
01

Overview

Phytoestrogen-Dhurakij Pundit University refers to an investigational botanical product derived from *Pueraria mirifica*, a Thai medicinal plant known as White Kwao Krua. The extract contains a variety of phytoestrogens, including isoflavonoids (such as puerarin, daidzin, and genistin), coumestans, and chromenes (notably miroestrol and deoxymiroestrol). These compounds function as natural selective estrogen receptor modulators (SERMs) that bind to estrogen receptors to mimic or modulate the effects of endogenous estrogen. Dhurakij Pundit University is evaluating the treatment in a Phase 2/3 clinical trial to determine its efficacy in improving serum lipid parameters—including triglycerides, total cholesterol, LDL, and HDL—in postmenopausal women with dyslipidemia.

Other names
Phytoestrogen from Pueraria MirificaWhite Kwao Krua
02

Targets

ESR2 (ERβ)ESR1 (ERα)

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