pulsatilla koreana nakai extract

Pulsatilla koreana Nakai extract is a herbal preparation derived from the root of the perennial plant Pulsatilla koreana Nakai, traditionally used in Korean and Chinese medicine. It has been employed for pain relief, anti-inflammation, edema reduction, treatment of malaria and fever, amoebic dysentery, internal hemorrhoids, and as an antiparasitic agent[1][5][6][8]. Modern research indicates that the extract exhibits multiple pharmacological activities including anti-inflammatory effects (notably via inhibition of JAK/STAT signaling), immunomodulation (especially Th2 cell-mediated responses), suppression of osteoclast differentiation (via downregulation of RANKL/NFATc1 pathway), anti-obesity effects (by modulating C/EBPα/β/δ and PPARγ pathways), antitumor activity (apoptosis induction in cancer cells), neuroprotection, cytotoxicity against certain cell lines, hypoglycemic action, and potential improvement in skin barrier function[1][4][5][6][7]. The main active constituents include saponins such as oleanolic saponins and lupinetype triterpenoid saponin; other compounds include anemonin and protoanemonin[5]. The mechanism involves modulation of immune signaling pathways such as JAK/STAT6/GATA3 for allergic diseases like atopic dermatitis or allergic rhinitis[1][7], inhibition of osteoclastogenesis for osteoporosis[6], regulation of adipogenesis-related transcription factors for obesity[5], among others.

Other names

Pulsatilla koreana Nakai extractPKN extractPulsatilla koreana root extract