Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
pulsatilla saponin D
- Development stage
- Preclinical
- Lead developer
- Sawai
- Modality
- Small Molecules
- Administration
- Intravenous, Intratumoral, Intraperitoneal, Intrathoracic, Inhalation
01
Overview
**Pulsatilla saponin D (SB365)** is a purified saponin compound isolated from the root of *Pulsatilla koreana* (or *Pulsatilla chinensis*), investigated primarily for its anti-cancer activity. Mechanistically, SB365 induces apoptosis, inhibits cell proliferation, and exhibits pronounced anti-angiogenic effects in multiple cancer types, including hepatocellular carcinoma, colorectal cancer, pancreatic cancer, gastric cancer, and gefitinib-resistant non-small cell lung cancer. Its mechanism of action involves inhibition of the PI3K/Akt/mTOR pathway, suppression of c-Met receptor phosphorylation and signaling, and downregulation of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α). Preclinical studies demonstrate reduced tumor growth and angiogenesis with minimal toxicity. It is being investigated as a novel chemotherapeutic agent and as a potential therapeutic option for treatment-resistant or advanced cancers[1][2][3][5][7][9][10].
- Brand names
- SB365SB-365SB 365
- Other names
- pulsatilla saponin D
02
Targets
HIF1A (Hypoxia-inducible factor 1-alpha)MET (Mesenchymal-epithelial transition factor receptor)VEGFA (Vascular endothelial growth factor A)
Beyond the preview
Go deeper on pulsatilla saponin D.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on pulsatilla saponin D.