Drug intelligence / Profile preview

pulsed radiofrequency + alpha lipoic acid

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral, Intravenous, Percutaneous
01

Overview

This is a combination therapy consisting of pulsed radiofrequency (a non-pharmacological, device-based pain management technique) and alpha-lipoic acid (a naturally occurring antioxidant and dietary supplement). Pulsed radiofrequency is used to modulate nerve function for the treatment of chronic pain by delivering short bursts of high-frequency electrical current to nervous tissue without causing significant tissue destruction. Alpha-lipoic acid acts as an antioxidant, supports mitochondrial energy metabolism, and has been studied primarily for its potential benefits in diabetic neuropathy, metabolic disorders, and as a general antioxidant. The combination may be explored in clinical or experimental settings for synergistic effects on neuropathic pain or nerve injury.

02

Targets

AKR1C2 (Aldo-keto reductase family 1 member C2)EPHX1 (Epoxide hydrolase 1)LTA4H (Leukotriene A4 hydrolase)DLAT (Dihydrolipoamide S-acetyltransferase)Kir (Inward-rectifier potassium channels)PDH (Pyruvate dehydrogenase complex)

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