Drug intelligence / Profile preview

punica granatum pleniflora

Development stage
Unknown
Lead developer
Shiraz University of Medical Sciences
Administration
Topical
01

Overview

Punica granatum pleniflora, known in Persian traditional medicine as Golnar, is a specific variety of pomegranate characterized by its sterile, double-petaled flowers. Unlike the fruit-bearing pomegranate, this variety is cultivated primarily for its medicinal properties. As a therapeutic agent, it is typically prepared as an aqueous extract or mouth rinse. It is rich in bioactive secondary metabolites, particularly tannins (such as punicalagin and ellagic acid) and polyphenols, which confer potent astringent, anti-inflammatory, and antimicrobial activities. In clinical settings, it has been investigated for its ability to manage oral health conditions, specifically gingivitis in diabetic patients, by reducing dental plaque accumulation and gingival inflammation. Its mechanism involves the precipitation of proteins and the inhibition of periodontal pathogens and pro-inflammatory mediators.

Brand names
GolnaarGolnar
Other names
punica granatum var. plenifloradouble-flower pomegranatedouble-flowered pomegranatePersian pomegranate
02

Targets

IL1B (Interleukin-1 beta)p38-MAPK (p38 mitogen-activated protein kinase)STAT3 (Signal Transducer and Activator of Transcription 3)TNFA (Tumor necrosis factor alpha (soluble))

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