purified corticotropin gel

Purified Cortrophin Gel is a prescription pharmaceutical formulation containing purified porcine-derived adrenocorticotropic hormone (ACTH 1-39) in gelatin for prolonged activity, supplied as a sterile, injectable gel[1][5][12]. **Mechanism of Action:** It stimulates the adrenal cortex via the melanocortin 2 receptor (MC2R), leading to increased production and secretion of endogenous adrenocortical hormones, including glucocorticoids and mineralocorticoids, which modulate inflammation and immune responses[1][5][12][2][7]. **Indications:** - Management of acute exacerbations/flairs in multiple sclerosis - Infantile spasms (seizures in children under age 2) - Adjunctive treatment for rheumatic disorders: psoriatic arthritis, rheumatoid arthritis (including juvenile), ankylosing spondylitis, acute gouty arthritis - Collagen diseases like systemic lupus erythematosus and systemic dermatomyositis (polymyositis) - Severe skin diseases (e.g., Stevens-Johnson syndrome, severe psoriasis), atopic dermatitis (eczema), and serum sickness - Severe allergic and inflammatory ophthalmic diseases (e.g., allergic conjunctivitis, keratitis, uveitis, optic neuritis) - Symptomatic sarcoidosis - Reduction of proteinuria in nephrotic syndrome (idiopathic or lupus origin, without uremia)[3][8][10][12][5][13] **It is not indicated for: scleroderma, osteoporosis, fungal infections, ocular herpes simplex, recent surgery, stomach ulcers, congestive heart failure, uncontrolled hypertension, primary adrenocortical insufficiency, adrenocortical hyperfunction, or hypersensitivity to porcine proteins.

Brand names

Purified Cortrophin Gel

Other names

corticotropin gelrepository corticotropincorticotropin (ACTH)