Drug intelligence / Profile preview

Purified Platelet Derived Growth Factors

Development stage
Unknown
Lead developer
Power of Platelets
Modality
Recombinant Proteins and Enzymes, Peptides
Administration
Intraarticular, Intralesional, Subcutaneous, Topical
01

Overview

Purified Platelet Derived Growth Factors (also known as L-GF or XelyoMax) is a standardized, lyophilized, pathogen-inactivated, and fibrinogen-depleted platelet releasate containing a supra-physiological concentration of multiple growth factors, including platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), and insulin-like growth factor (IGF). Developed by Power of Platelets and Consumed, XelyoMax is prepared from allogeneic human platelets using a patented process that ensures viral inactivation and standardization of growth factor concentrations. It is designed as a refined, off-the-shelf alternative to conventional autologous platelet-rich plasma (PRP) therapy, eliminating the need for patient blood draws and providing a consistent, water-soluble product with an extended shelf life. XelyoMax is primarily developed for regenerative medicine applications, including the treatment of musculoskeletal disorders such as knee osteoarthritis, plantar fasciitis, subacromial impingement syndrome, and tennis elbow, as well as wound healing, skin rejuvenation, and androgenetic alopecia.

Brand names
XelyoMaxXelyoMax LGF
Other names
Lyophilized Growth Factorsplatelet-derived lyophilized growth factors
02

Targets

PDGFRA (Platelet-derived growth factor receptor alpha)PDGFRB (Platelet-derived growth factor receptor beta)EGFR (Epidermal growth factor receptor)FGFR1 (Fibroblast growth factor receptor 1)IGF-1R (Insulin-like growth factor 1 receptor)TGFBR1TGFBR2 (TGF-β receptor type 2)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)

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