purvalanol

Purvalanol is a synthetic small molecule that functions as a potent and selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK1 (also known as Cdc2), CDK2, and CDK5. It belongs to the class of organic compounds known as 6-aminopurines. By inhibiting these kinases, purvalanol disrupts cell cycle progression—most notably causing G2-M phase arrest—and can induce apoptosis in cancer cells. In addition to its effects on the cell cycle machinery, purvalanol A has been shown to suppress c-Src tyrosine kinase activity and modulate polyamine metabolism by upregulating enzymes such as spermidine/spermine N1-acetyltransferase (SSAT) and polyamine oxidase (PAO). These actions contribute to its pro-apoptotic effects in various cancer cell lines. Purvalanol is used primarily in research settings for studying cell cycle regulation and potential anticancer mechanisms[1][3][7][10].

Other names

PurvalanolPurvaLCH61386CH-61386CH 61386CS-1631CS1631CS 1631(R)-Purvalanol A