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Pyolysin
- Development stage
- Unknown
- Lead developer
- Serumwerk Bernburg
- Modality
- Split/Subunit Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Small Molecules, Whole Cell Cancer Vaccines → Cancer Vaccines → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Topical
01
Overview
Pyolysin is a topical wound-healing ointment manufactured by Serum-Werk Bernburg. It contains a bacterial lysate (culture filtrate) derived from several common pathogens, including *Staphylococcus aureus*, *Streptococcus pyogenes*, *Escherichia coli*, *Enterococcus faecalis*, and *Pseudomonas aeruginosa*. This lysate acts as a local immunostimulant, enhancing the recruitment of phagocytes and promoting the formation of granulation tissue to accelerate the healing of infected or poorly healing wounds, such as leg ulcers and pressure sores. The formulation also includes salicylic acid, which provides keratolytic and antimicrobial activity, and zinc oxide, which acts as a skin protectant and astringent.
- Brand names
- PyolysinPyolysin-Salbe
- Other names
- Pyolysin ointment
02
Targets
TLR9 (Toll-like receptor 9)TLR2 (Toll-like Receptor 2)
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