Pyr3

Pyr3 is a selective small molecule inhibitor of the canonical transient receptor potential channel 3 (**TRPC3**), used primarily in research settings to block TRPC3-mediated calcium influx (IC50 ~0.7 μM), resulting in inhibition of downstream calcium-dependent signaling pathways. It suppresses activation of nuclear factor of activated T cells (NFAT) and inhibits hypertrophic responses in cardiomyocytes. Pyr3 is not an approved pharmaceutical; it is most commonly applied in cardiovascular, neuronal, and smooth muscle cell biology studies to dissect TRPC3 function[1][2][3][8].

Other names

1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acidethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate