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pyrintegrin
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Intraperitoneal, Implant
01
Overview
Pyrintegrin is a small molecule 2,4-disubstituted pyrimidine that acts as a potent agonist of β1-integrin (specifically α3β1 integrin). It was originally identified in a high-throughput chemical screen by researchers at The Scripps Research Institute to promote the survival and self-renewal of human embryonic stem cells (hESCs) following single-cell dissociation by enhancing cell-extracellular matrix (ECM) adhesion-mediated integrin signaling. Pyrintegrin has also been investigated for its protective effects on podocytes in focal segmental glomerulosclerosis (FSGS) and its ability to promote adipogenesis in stem/progenitor cells, as well as mitigating fibroblast senescence in diabetic mellitus erectile dysfunction (DMED).
- Other names
- N-(Cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]benzenesulfonamide
02
Targets
α3β1 (Integrin alpha 3 beta 1)ITGB1 (Integrin beta-1)
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