pyripyropene A

Pyripyropene A is a fungal-derived small molecule that potently and selectively inhibits acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2), an enzyme involved in the esterification of cholesterol in the intestine and liver. It is highly selective for ACAT2 over ACAT1 (IC50 ~70 nM for ACAT2, >80 μM for ACAT1), and in animal models, oral administration reduces intestinal cholesterol absorption, plasma cholesterol, LDL and VLDL cholesterol, hepatic cholesterol, and atherosclerotic lesions. Pyripyropene A has been used as a lead compound for the development of anti-atherosclerotic agents but is primarily a tool compound for research use in ACAT2 biology and cholesterol metabolism studies[1][3][4][10].

Other names

(+)-Pyripyropene APPPAFO-1289AFO1289AFO 1289Apyripyropene AACAT2 inhibitorACAT-2 inhibitorACAT 2 inhibitor