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pyropheophorbide phosphatidic acid
- Development stage
- Preclinical
- Lead developer
- University of North Carolina at Chapel Hill
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intravenous
01
Overview
Pyropheophorbide phosphatidic acid (Pyro PA) is a lipid-modified photosensitizer derived from pyropheophorbide-a, a chlorophyll-based molecule. It is designed for use in photodynamic therapy (PDT), where it is typically encapsulated in nanocarriers such as lipid-calcium phosphate (LCP) nanoparticles. Upon activation by specific wavelengths of light, Pyro PA generates reactive oxygen species (ROS) that induce localized cytotoxicity in tumor cells. In research settings, it has been targeted to sigma receptors using ligands like aminoethylanisamide (AEAA) and combined with gene therapies, such as EGFR siRNA, to enhance therapeutic efficacy in head and neck squamous cell carcinoma.
- Other names
- pyropheophorbide phosphatydic acidpyropheophorbide-a phosphatidic acidPyro-PA
02
Targets
σR (Sigma receptors)
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