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pyrotinib + paclitaxel
- Development stage
- Phase 2
- Lead developer
- Hengrui Therapeutics
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Pyrotinib + paclitaxel is a combination therapy consisting of an irreversible pan-ErbB tyrosine kinase inhibitor and a microtubule-stabilizing taxane. Pyrotinib targets the intracellular kinase domains of EGFR, HER2, and HER4, inhibiting downstream signaling pathways like PI3K/Akt and MAPK. Paclitaxel interferes with microtubule dynamics during mitosis, leading to cell cycle arrest and apoptosis. This combination is primarily investigated for HER2-positive malignancies, including advanced or metastatic gastric and gastroesophageal junction cancers, where it aims to overcome resistance and provide synergistic anti-tumor activity. Clinical trials, such as those sponsored by He'nan Provincial People's Hospital, evaluate this regimen in patients who have failed prior therapies.
- Brand names
- Airuini
- Other names
- pyrotinib + paclitaxel
02
Targets
TUBB (Tubulin (alpha and beta subunits))EGFR (Epidermal growth factor receptor)ERBB3 (Erb-b2 receptor tyrosine kinase 3)ERBB4 (Erb-b2 receptor tyrosine kinase 4)ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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