Drug intelligence / Profile preview

PYTX-002

Development stage: Preclinical
Lead developer: Papyrus Therapeutics
Modality: Gene Therapies

Overview

PYTX-002 is a gene replacement therapy developed by Papyrus Therapeutics Inc. It is based on the OPCML tumor suppressor and is designed to condition the tumor microenvironment. The drug aims to enhance the activation and efficacy of CAR-T cell therapy, particularly in the challenging treatment of solid tumors.

Targets

AXL (AXL receptor tyrosine kinase)EPHA2 (Ephrin type-A receptor 2)FGFR1 (Fibroblast growth factor receptor 1)FGFR3 (Fibroblast growth factor receptor 3)ERBB2 (Erb-b2 receptor tyrosine kinase 2)ERBB4 (Erb-b2 receptor tyrosine kinase 4)OPCML (Opioid binding protein/cell adhesion molecule-like)

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