PYY1-36

PYY1-36 is a naturally occurring, full-length (36-amino acid) peptide hormone of the neuropeptide Y family, produced primarily by L-cells in the distal gut (ileum and colon) in response to food intake[2][4][5]. It is one of two major forms of Peptide YY (the other being PYY3-36), and acts as an endogenous ligand for several Y-receptor subtypes including Y1, Y2, Y4, and Y5 receptors[2]. Unlike its truncated form PYY3-36—which selectively activates the neuropeptide Y2 receptor to suppress appetite—PYY1-36 binds with high affinity to all four receptor subtypes. Through these interactions it modulates gastrointestinal motility and secretion (inhibiting gastric acid secretion, gastric emptying, small bowel/colonic chloride secretion), reduces pancreatic exocrine/insulin secretion, promotes natriuresis and elevates blood pressure[2][5]. In the central nervous system it can cross the blood-brain barrier; acting via different receptors it may increase appetite through activation of Y1/Y5 receptors[2]. Research has explored its potential therapeutic use for metabolic disorders such as diabetes due to effects on beta-cell function/survival via NPYR1 activation[6], but clinical studies suggest that unlike PYY3-36 it does not significantly reduce energy intake or induce satiety when administered exogenously in humans[9][10].

Other names

Peptide YY 1-36peptide tyrosine tyrosine 1-36pancreatic peptide YY 1-36