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PZ04

Development stage: Unknown
Lead developer: The First Medical Center of Chinese PLA General Hospital
Modality: CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Intravenous

Overview

PZ04 is an autologous CAR-T cell therapy engineered to target CD19 and express a PD-1 blocking antibody (Ab21). Developed by the Chinese People's Liberation Army (PLA) General Hospital, it is intended for the treatment of CD19-positive hematological malignancies, such as B-cell lymphomas and leukemias. By combining CAR-mediated targeting of CD19 with the secretion or expression of a PD-1 antibody, PZ04 aims to overcome the immunosuppressive effects of the PD-1/PD-L1 pathway, potentially improving the persistence and anti-tumor efficacy of the T cells within the tumor microenvironment.

Other names: PD-1Ab21-CD19CAR-T cellsPD1Ab21-CD19CAR-T cellsPD 1Ab21-CD19CAR-T cells

Targets

CD19 (B lymphocyte antigen CD19)PDCD1 (Programmed cell death protein 1 receptor)CD274 (Programmed cell death protein 1 ligand 1)

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