Qβ-oxycodone

Qβ-oxycodone is an investigational **opioid vaccine** that uses **Qβ bacteriophage virus-like particles** as a carrier platform to display an oxycodone hapten and induce anti-oxycodone antibodies. The intended mechanism is pharmacokinetic sequestration of oxycodone in the bloodstream, thereby reducing drug distribution to the brain and blunting opioid effects relevant to overdose and opioid use disorder. Based on the published preclinical study, the candidate produced high-titer, high-avidity, and durable antibody responses in mice, showed room-temperature stability for more than two weeks, and was also immunogenic in rhesus macaques after intramuscular administration. No specific commercial developer or manufacturer was clearly identified in the provided source, and the program appears to be at the preclinical research stage.

Other names

Q beta oxycodoneQβ bacteriophage virus-like particle oxycodone vaccineoxycodone conjugated Qβ virus-like particle vaccine