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Q Fever LPS Conjugate Vaccine
- Development stage
- Preclinical
- Lead developer
- Hilleman Laboratories
- Modality
- Split/Subunit Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
01
Overview
The Q Fever LPS Conjugate Vaccine is a preclinical vaccine candidate being developed by Hilleman Laboratories for the prevention of Q Fever, a zoonotic infection caused by the bacterium *Coxiella burnetii*. The vaccine utilizes a conjugate platform where the lipopolysaccharide (LPS) of *C. burnetii* is chemically linked to a carrier protein. This design aims to overcome the limitations of traditional whole-cell vaccines, which can cause severe hypersensitivity reactions in individuals previously exposed to the pathogen. By conjugating the LPS antigen, the vaccine is intended to convert the T-cell independent carbohydrate antigen into a T-cell dependent one, thereby inducing a more robust and long-lasting immune response with an improved safety profile.
- Other names
- Coxiella burnetii LPS-conjugate vaccineQ fever lipopolysaccharide conjugate vaccine
02
Targets
Coxiella burnetii phase I lipopolysaccharide O-antigen epitopeCbLPS-I (Coxiella burnetii phase I lipopolysaccharide)
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