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Drug intelligence / Profile preview
Q fever multi-epitope vaccine
- Development stage
- Preclinical
- Lead developer
- EpiVax
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
Q fever multi-epitope vaccine is a T-cell-targeted vaccine candidate being developed by the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital, in collaboration with EpiVax and other partners under the Q-VaxCelerate consortium. The vaccine is designed to protect against Q fever, a zoonotic disease caused by the intracellular bacterium *Coxiella burnetii*, while avoiding the severe reactogenicity associated with the currently available whole-cell vaccine (Q-VAX). It utilizes immunoinformatically selected, highly conserved *C. burnetii* CD4+ T-cell epitope clusters to stimulate a protective, pathogen-specific cell-mediated immune response. Preclinical development has evaluated delivery of these epitope concatemers using viral vectors, such as adenovirus (ChAdOx2) and Modified Vaccinia Ankara (MVA), in animal models.
- Other names
- Q-VaxCelerateT cell-targeted multi-epitope vaccine for Q feverT-cell targeted human Q fever vaccine
02
Targets
HLA-DR (Human leukocyte antigen DR)γδ TCR (T-cell receptor)
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