Q-VD-OPh

Q-VD-OPh is a potent, cell-permeable, and irreversible broad-spectrum caspase inhibitor. It is designed to inhibit a wide range of caspases, including caspase-1, -3, -7, -8, -9, -10, and -12, thereby effectively blocking the apoptotic cell death pathway. Compared to earlier generation inhibitors like Z-VAD-FMK, Q-VD-OPh demonstrates significantly higher potency, superior stability, and markedly reduced cellular toxicity, making it a preferred tool compound for both in vitro and in vivo research. It is frequently utilized in studies to distinguish between different modalities of cell death, such as apoptosis and ferroptosis, and to investigate the role of caspases in neurodegeneration, inflammation, and oncology. Notably, Q-VD-OPh does not inhibit other proteases like calpains or cathepsins at concentrations that fully suppress caspase activity.

Other names

Quinoline-Val-Asp-Difluorophenoxymethyl KetoneQ-VD-OPHQuinoline-Val-Asp(OMe)-OPh