Drug intelligence / Profile preview

QHRD211

Development stage: Unknown
Lead developer: Jiangsu Zhonghong Bioengineering Pharmaceutical Research Institute
Modality: Recombinant Proteins and Enzymes
Administration: Subcutaneous

Overview

QHRD211 is a long-acting recombinant human growth hormone (rhGH) developed by Jiangsu Zhonghong Bioengineering Pharmaceutical Research Institute for the treatment of pediatric growth hormone deficiency (PGHD). The drug is a PEGylated formulation of somatropin, designed to extend the circulating half-life of the hormone and allow for once-weekly subcutaneous administration, compared to the daily injections required by conventional rhGH therapies. QHRD211 acts as an agonist at the growth hormone receptor (GHR), triggering the JAK2-STAT5 signaling pathway to stimulate the production of insulin-like growth factor 1 (IGF-1), which promotes linear bone growth and metabolic regulation. It is currently in Phase 3 clinical development in China.

Other names: Long-acting recombinant human growth hormonePEGylated recombinant human growth hormone

Targets

GHR (Growth hormone receptor)

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