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Qi-Gui Fu-Yuan
- Development stage
- Unknown
- Lead developer
- Gansu Provincial Hospital of Traditional Chinese Medicine
- Administration
- Oral
01
Overview
Qi-Gui Fu-Yuan is a Traditional Chinese Medicine (TCM) herbal formula primarily composed of *Astragalus membranaceus* (Huangqi) and *Angelica sinensis* (Danggui). It is designed to "tonify Qi" and "invigorate blood," and is commonly utilized in clinical settings in China for postoperative recovery, particularly following orthopedic surgeries such as hip or knee arthroplasty. The formula is hypothesized to alleviate postoperative fatigue syndrome (POFS) and prevent skeletal muscle atrophy by modulating inflammatory responses, reducing oxidative stress, and potentially regulating the TGF-β1/Smads and PI3K/Akt/mTOR signaling pathways. Clinical research, often conducted at institutions like the Gansu Provincial Hospital of TCM, has investigated its efficacy in improving physical function and reducing inflammatory markers like IL-6 and TNF-α in surgical patients.
- Other names
- Qigui Fuyuan GranulesQigui Fuyuan DecoctionQigui Fuyuan Fang
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))TGFB1 (Transforming growth factor Beta-1 proprotein)IL-6 (Interleukin 6)
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