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Qianghuo Dihuang Tang
- Development stage
- Preclinical
- Lead developer
- Shanghai Municipal Hospital of Traditional Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Qianghuo Dihuang Tang is a Traditional Chinese Medicine (TCM) decoction used for the treatment of rheumatoid arthritis and other inflammatory joint conditions. The formula typically features *Notopterygium incisum* (Qianghuo) and *Rehmannia glutinosa* (Dihuang) as its primary components. A specific variant, Shenshi Qianghuo Dihuang Decoction, is currently under clinical investigation by the Shanghai Traditional Chinese Medicine Hospital to evaluate its efficacy in managing rheumatoid arthritis symptoms, particularly joint pain and swelling, by addressing dampness and inflammation according to TCM principles.
- Other names
- Shenshi Qianghuo Dihuang DecoctionQianghuo Dihuang Decoction羌活地黄汤渗湿羌活地黄汤
02
Targets
ESR1 (ERα)IL1B (Interleukin-1 beta)IL-6 (Interleukin 6)JNK (Mitogen-activated protein kinase kinase kinase family)MMP2 (Matrix metalloproteinase-2)AGER (RAGE)HIF1A (Hypoxia-inducible factor 1-alpha)IL-17A (Interleukin-17A)MEKPI3K (Phosphoinositide-3-kinase regulatory subunit 6)AKT (RAC-alpha serine/threonine-protein kinase)TNFA (Tumor necrosis factor alpha (soluble))CREB (cAMP response element-binding protein)
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