Drug intelligence / Profile preview

Qibai Pingfei Granules

Development stage
Phase 2
Lead developer
Lianyungang Kanion
Modality
Small Molecules
Administration
Oral
01

Overview

Qibai Pingfei Granules is a Traditional Chinese Medicine (TCM) compound developed by Jiangsu Kanion Pharmaceutical for the treatment of chronic obstructive pulmonary disease (COPD). Approved by the China National Medical Products Administration (NMPA) in December 2021 as a Class 1.1 innovative Chinese medicine, it is specifically indicated for patients in the stable phase of COPD who exhibit the TCM syndrome of Qi deficiency, phlegm obstruction, and blood stasis. The formulation is derived from clinical experience and aims to tonify Qi, strengthen the spleen, and clear phlegm. Pharmacological studies suggest that it functions by inhibiting inflammatory signaling pathways, reducing airway remodeling, and enhancing antioxidant defenses. Clinical trials have demonstrated its efficacy in improving exercise tolerance, reducing the frequency of acute exacerbations, and alleviating respiratory symptoms such as cough and shortness of breath.

Brand names
Qibai Pingfei Granules
Other names
Qibai Pingfei Keli芪白平肺颗粒
02

Targets

AKT (RAC-alpha serine/threonine-protein kinase)HMOX1 (Heme oxygenase 1)IL-6 (Interleukin 6)IL8 (C-X-C Motif Chemokine Ligand 8)MMP9 (Matrix metalloproteinase-9)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)NF-κBPI3K (Phosphoinositide-3-kinase regulatory subunit 6)TGFB1 (Transforming growth factor Beta-1 proprotein)TNFA (Tumor necrosis factor alpha (soluble))

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