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Qidong Huoxue Yin
- Development stage
- Unknown
- Lead developer
- Zhejiang Hospital
- Modality
- Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
- Administration
- Oral
01
Overview
Qidong Huoxue Yin is a traditional Chinese medicine (TCM) herbal formula used primarily for the treatment of acute lung injury (ALI) and related inflammatory conditions. It is a multi-herb decoction with demonstrated anti-inflammatory and immunomodulatory effects in preclinical models. Mechanistically, it promotes the development of regulatory T cells (CD4+CD25+Foxp3+ Tregs) by enhancing Foxp3 transcription through increased acetylation at the Foxp3 promoter in CD4+ T cells and by inhibiting histone deacetylase activity. Additionally, it stabilizes β-catenin in macrophages to further support Treg development and modulates cytokine profiles to restore immune balance within lung tissue. Other studies indicate that it inhibits inflammation via suppression of caveolin-1 signaling pathways and downregulation of pro-inflammatory cytokines such as TNF-α, IL-6, IL-1β, as well as MyD88 expression[1][2][4][5]. Its primary clinical application is for ALI/ARDS; however, its use may extend to other inflammatory or immune-mediated pulmonary diseases.
- Brand names
- Qidong Huoxue Yin
- Other names
- Qi-Dong-Huo-Xue-YinQidonghuoxue DecoctionQi Dong Huo Xue Yin
02
Targets
Forkhead box P3 promoter (Foxp3 promoter)HDAC1 (Histone Deacetylase 1)HDAC6 (Histone deacetylase 6)HDAC9MYD88 (Myeloid differentiation primary response protein MyD88)CTNNB1 (Beta-catenin)CAV1 (Caveolin-1)FOXP3 (Forkhead box protein P3)
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