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Qidongyixin
- Development stage
- Unknown
- Lead developer
- Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Qidongyixin is a Traditional Chinese Medicine (TCM) preparation developed by Dongzhimen Hospital, which is affiliated with the Beijing University of Chinese Medicine. It is primarily used to treat heart qi deficiency syndrome, particularly in cancer patients experiencing cardiotoxicity as a side effect of chemotherapy, such as anthracycline-induced myocardial injury. The formula typically consists of herbal components including *Astragalus membranaceus* (Huangqi) and *Ophiopogon japonicus* (Maidong). Qidongyixin exerts its therapeutic effects by protecting cardiomyocytes from oxidative stress and apoptosis, often through the modulation of the PI3K/Akt signaling pathway. It is commonly administered as an oral liquid or decoction and is recognized as an in-hospital preparation in China.
- Brand names
- Qidong Yixin oral liquid
- Other names
- Qidong Yixin Oral LiquidQidong Yixin DecoctionQidong Yixin Formula气冬益心
02
Targets
PI3K (Phosphoinositide-3-kinase regulatory subunit 6)AKT (RAC-alpha serine/threonine-protein kinase)CASP3 (Caspase-3)
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