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qigu capsules
- Development stage
- Unknown
- Lead developer
- Xiamen Traditional Chinese Medicine
- Administration
- Oral
01
Overview
Qigu Capsules (芪骨胶囊) is a Traditional Chinese Medicine (TCM) compound preparation developed and manufactured by Xiamen Traditional Chinese Medicine Co., Ltd. (under the brand name Dinglu). It is officially approved in China for the treatment of osteoporosis, particularly targeting postmenopausal and senile osteoporosis associated with kidney deficiency and blood stasis patterns. The formulation is composed of several herbal ingredients, including *Astragalus membranaceus*, *Epimedium brevicornu*, *Drynaria fortunei*, *Rehmannia glutinosa*, and *Salvia miltiorrhiza*. Pharmacological studies indicate that Qigu Capsules improves bone mineral density and bone microarchitecture by promoting osteoblast-mediated bone formation and inhibiting osteoclast-mediated bone resorption. This therapeutic effect is largely attributed to the modulation of the OPG/RANKL signaling pathway and the phytoestrogenic activity of its constituents.
- Brand names
- Qigu Capsules芪骨胶囊Dinglu
- Other names
- 芪骨胶囊
02
Targets
AKT (RAC-alpha serine/threonine-protein kinase)AMPK (Adenosine monophosphate–activated protein kinase)FOXO3 (Forkhead box protein O3)HIF1A (Hypoxia-inducible factor 1-alpha)NF-κBPI3K (Phosphoinositide-3-kinase regulatory subunit 6)PPARGC1A (Peroxisome proliferator–activated receptor gamma coactivator 1-alpha)OPG (Osteoprotegerin)RANKL (Receptor Activator for Nuclear Factor-kappa B Ligand)mTOR (Mammalian target of rapamycin kinase)ER (Estrogen receptor)
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