Drug intelligence / Profile preview

Qigui Yishen Prescription

Development stage
Preclinical
Lead developer
First Affiliated Hospital of Soochow University
Administration
Oral
01

Overview

**Qigui Yishen Prescription** is an investigational traditional Chinese multi-herb decoction for kidney disease. It has been studied clinically in chronic kidney disease and in platinum anticancer therapy-associated acute and chronic kidney injury. In a unilateral ureteral obstruction animal model, the decoction reduced renal interstitial fibrosis and was associated with lower renal plasminogen activator inhibitor-1, transforming growth factor beta 1, and collagen I expression and higher thrombomodulin expression. These findings are preclinical and do not establish a defined direct molecular target or clinical efficacy. ([chictr.org.cn](https://www.chictr.org.cn/showproj.aspx?proj=134648))

Other names
QiGuiYiShen DecoctionQigui Yishen DecoctionQigui Yishen PrescriptionQigui-Yishen decoction
02

Targets

THBD (Thrombomodulin)COL1 (Collagen type I)TGFB1 (Transforming growth factor Beta-1 proprotein)PAI-1 (Plasminogen activator inhibitor type 1)

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