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QiGuiYiShen Decoction
- Development stage
- Preclinical
- Modality
- Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
- Administration
- Oral
01
Overview
QiGuiYiShen Decoction is a traditional Chinese medicine (TCM) compound herbal preparation primarily used to delay or prevent renal fibrosis, particularly in the context of chronic kidney disease (CKD). The formula is composed mainly of Angelica sinensis and Astragalus membranaceus, among other herbs. Its mechanism involves multiple components acting on multiple targets and pathways associated with renal fibrosis. Specifically, it regulates the expression of thrombomodulin (TM), plasminogen activator inhibitor-1 (PAI-1), transforming growth factor-beta 1 (TGF-β1), and collagen type I (Col I). By increasing TM expression and reducing PAI-1 levels in kidney tissues, it helps mitigate inflammation and fibrotic processes that contribute to CKD progression[1]. The decoction exemplifies the TCM approach of multi-targeted intervention for complex diseases.
- Brand names
- QiGuiYiShen Decoction
- Other names
- Qigui-Yishen decoctionQigui Yishen decoction
02
Targets
TGFB1 (Transforming growth factor Beta-1 proprotein)COL1 (Collagen type I)PAI-1 (Plasminogen activator inhibitor type 1)THBD (Thrombomodulin)
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